Перегляд за автором "Dubey, I.Ya."

Результати 1-10 з 10

Design and study of telomerase inhibitors based on G-quadruplex ligands

Negrutska, V.V.; Dubey, L.V.; Ilchenko, M.M.; Dubey, I.Ya. (Вiopolymers and Cell, 2013)

In this review we have summarized the results of our recent research on telomerase inhibitors and G-quadruplex DNA ligands. A series of potential enzyme inhibitors were synthesized and studied. These compounds were based ...
Development and characterization of porous functionalized collagen scaffolds for delivery of FGF-2

Pokholenko, Ia.O.; Chetyrkina, M.D.; Dubey, L.V.; Dubey, I.Ya.; Moshynets, O.V.; Sheludko, E.V.; Shpylova, S.P.; Degtiarova, M.I.; Kordium, V.A. (Вiopolymers and Cell, 2014)

Aim. To develop the porous functionalized collagen scaffold for the delivery of FGF-2 and studying its properties in vitro and in vivo. Methods. Porous collagen scaffolds were prepared by freeze- drying collagen I solutions ...
Inhibition of in vitro transcription by 2-arylidene derivatives of thiazolo[3,2-α]benzimidazol-3(2H)-one

Palchykovska, L.G.; Alexeeva, I.V.; Negrutska, V.V.; Kostyuk, Yu.K.; Indychenko, T.M.; Kostenko, O.M.; Kryvorotenko, D.V.; Shved, A.D.; Dubey, I.Ya. (Вiopolymers and Cell, 2010)

Aim. To evaluate a series of 2-substituted thiazolo[3,2-α]benzimidazolones as potential transcription inhibitors. Methods. Compounds were tested in a model transcription system based on T7 RNA polymerase. Results. The ...
Interaction of cationic porphyrin-imidazophenazine conjugates with DNA quadruplex: FID assay and quantum-chemical modeling

Didan, Yu.V.; Ilchenko, M.M.; Negrutska, V.V.; Dubey, L.V.; Ryazanova, O.A.; Dubey, I.Ya. (Вiopolymers and Cell, 2018)

Aim. To study the efficiency of tricationic porphyrin–imidazo[4,5-b]phenazine conjugate and its Zn(II) and Mn(III) complexes as G-quadruplex (G4) DNA ligands. Methods. FID (Fluorescent Intercalator Displacement) assay was ...
Lepidine Orange derivative as a new dye for sensitive fluorescent detection of DNA

Didan, Yu.V.; Kryvorotenko, D.V.; Negrutska, V.V.; Dubey, I.Ya. (Вiopolymers and Cell, 2013)

Aim. To study new cyanine dye LO-7 as a reagent for dsDNA visualization in electrophoretic gels. Methods. Gel electrophoresis, restriction, fluorescence detection, mobility shift assay. Results. LO-7 binds to DNA to form ...
Preparation of bifunctional silica polymer support for the synthesis of 3'-labeled oligonucleotides

Dubey, L.V.; Dubey, I.Ya. (Біополімери і клітина, 2005)

Preparation of a silica polymer support with a linker arm containing protected amino and hydroxy groups is described. O-Benzotriazol-1-yl-N,N,N'‚N'-tetramethyluronium hexafluorophosphate (HBTU) in the presence of ...
Preparation of the fluorescein reagent for solid-phase oligonucleotide 5'-labelling and its use for the synthesis of fluorescently labelled PCR primers for HIV-1 detection

Dubey, I.Ya.; Fedoryak, O.D.; Tkachak, O.M.; Fedoryak, D.M. (Биополимеры и клетка, 1995)

The preparative synthesis of fluorescein H-phosphonate reagent for solid phase 'labelling of oligonucteotides is described. Fluorescein-labelted thymidine and two PCR primers for HIV-1 detection were synthesized using this ...
Spectroscopic study of binding of a cationic Pheophorbide-a to an antiparallel quadruplex Tel22

Ryazanova, O.A.; Zozulya, V.N.; Voloshin, I.M.; Glamazda, A.Yu.; Dubey, I.Ya.; Dubey, L.V.; Karachevtsev, V.A. (Вiopolymers and Cell, 2019)

Aim. To study the binding of a water-soluble cationic Pheophorbide-a derivative (CatPheo-a) ta a Na+–stabilized antiparallel quadruplex formed by 22-mer oligonucleotide d[AG3(T2AG3)3] of the human DNA telomeric sequence ...
Studies on interaction of oligoadenylates with proteins in vitro by MALDI-TOF mass spectrometry

Levchenko, S.M.; Rebriev, A.V.; Tkachuk, V.V.; Dubey, L.V.; Dubey, I.Ya.; Tkachuk, Z.Yu. (Вiopolymers and Cell, 2013)

Aim. To investigate the ability of «core» 2'-5'- and 3'-5'-oligoadenylates (OA) to interact with α-interferon – a key protein of the 2'- 5'-OAS/RNAase L system responsible for antiviral cell defense. Methods. MALDI-TOF ...
Telomerase inhibition by new di- and trisubstituted acridine derivatives

Negrutska, V.V.; Saraieva, I.V.; Kostina, V.G.; Alexeeva, I.V.; Lysenko, N.A.; Dubey, I.Ya. (Вiopolymers and Cell, 2016)

Aim. To study a series of new acridine derivatives containing two basic fragments able to bind to quadruplex DNA at C-4 and C-9 positions as potential telomerase inhibitors. Methods. TRAP assay was used to determine the ...

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Перегляд за автором "Dubey, I.Ya."

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